Figure 4.
The effect of removing bystander killing or spleen retention on parasite virulence. (a) Simulated uninfected RBCs and (b) corresponding simulated infected RBC numbers (as in figure 1) obtained by taking individual-specific starting RBC densities and individual bt values, and setting bt to zero for time-steps when bt < 0. (c) Observed minimum uninfected RBCs (×10−2 μl–1, x-axis) versus simulated minimum uninfected RBC obtained as described earlier (y-axis); vertical and horizontal lines indicate quartiles across individuals; the trough is deeper when no bystander killing is implemented for mice infected by several of the clones; exceptions include many mice in the AD and AS clones.