Figure 2. Cytotoxic Effect of SynB1-ELP-KLAK in Breast Cancer Cells.
The cytotoxic effect of SynB1-ELP1-KLAK was evaluated in (A) MCF-7, (B) MDA-MB-231 and (C) E0771 cells at the indicated concentrations. MCF-7 cells were also treated with the control polypeptides - SynB1-ELP2-KLAK, SynB1-ELP1 or SynB1-ELP2 at 80 µM and compared with the effect at the same concentration of SynB1-ELP1-KLAK (D). Cell counts were taken using a Coulter Counter. % survival is calculated with respect to untreated cells at 37 °C. Data represents mean ± S.E.M of at least three independent experiments. * indicates p<0.001 for treatment vs. untreated control at 37 °C.