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Reactive astrocytes show a delayed and transient upregulation of cell-cycle genes, suggesting modest proliferation after injury. The relative expression of cell-cycle genes in reactive astrocytes over time was represented on a line graph. The expression of early-phase cyclin D is upregulated at 1 d after MCAO. The expression of late-phase cell-cycle genes and proliferation marker ki67 is upregulated at 3 d. All cell-cycle gene expression is returning toward baseline by 7 d after MCAO.
