Table 3.
Groupings of induced genes based on gene ontology
| Gene Ontology grouping | Genes |
|---|---|
| Genes induced in astrocytes after MCAO | |
| ECM binding/modification/adhesion | CD24A, CD44, JUB, ChL4, COL6A1, IGFBP3, COL6A2, COL12A1, ICAM1, LGALS1, PVR, THBS1, THBS2, TGFBI, VCAN, CHI3L1, DPYSL3, ECM1, ADAM12, ADAMTS4, CELA1, ADAMTS5, GALNTL2, LGALS3, NAV2, FGL2, NETO2, OLFML3 |
| Basic metabolic processes | AKR1B8, ASPG, BCAT1, ODC1, ESD, PDE3B, ASNS, CYP1B1, B3GNT5, GCNT2, GGTA1, OASL2, CTPS, UCK2 |
| Transcription factors | BCL3, CDBPD, KLF5, KLF6, TGIF1, AHR, FOSL1, HMGA, FOSL2, SBNO2 |
| Cell cycle | NEK6, S100A6, ZWINT, CDT1, CCND1, CDK6, CDKN1A, GADD45A, HMGA2, EMP1 |
| Signal transduction | BDKRB2, GADD45B, SPHK1, SOCS3, CAMK2D, RHOJ, SPHKAP, ODZ2, SHISA6 |
| Unclassified immune response | CD14, C3, NUPR1, PROCR, THBD, TLR4, MPA2L, PLP2, PTX3, LCN2 |
| Cytokines | CLCF1, CCL2, CXCL1, CXCL10, CXCL2, IL6, LIF, SPP1 |
| Actin binding | ARPC1B, ACTN1, FSCN1, FLNC, FLNA, SYNPO, MSN, TAGLN2 |
| Metal ion transport | STEAP4, CP, STEAP1, SLC10A6, SLC39A14, SLC5A3 |
| Structural proteins | AKAP12, GFAP, LMNA, NES, TUBA1A, TUBB6, VIM |
| Lipid metabolic process | AGPAT9, CAV1, LASS6, PLA2G4A, CH25H, HPGD, PTGS2 |
| Peptidase inhibitors | CD109, A2M, SERPINA3N, SERPINE1, SERPING1, TIMP1 |
| Membrane regulation | ANXA1, ANXA2, ANXA7, ANXA3, S100A10, S100A11 |
| Response to oxidative stress | GPX1, HMOX1, SRXN1, TXNRD1 |
| Regulation of programmed cell death | GCH1, MCL1, LITAF, EDA2R, SULF1 |
| Response to interferon β | IFI202B, IFITM3, IFI203, IIGP1, GBP3 |
| Peptidase activity | PAPPA, PRSS23, USP18, LONRF1 |
| Neuron activity and development | GAP43, VGF, CACNG5, SYT4 |
| RNA processing and translation | NHP2, NOP58, EIF1A, PCBP3 |
| Signaling receptors | IL13RA1, IL6RA, OSMR, S1PR3, MET, TNFRSF12A |
| Growth factors | BDNF, CTGF, GDF15 |
| Zinc binding | NT5E, RNF125, RNF19B |
| Mitochondria | OCIAD2, MRPS6, MTHFD2 |
| Miscellaneous | CPNE8, EII2, FAM129B, GRB10, HSPB1, HSPB6, TMEM74, KLHDC8A, LRRC59, LRG1, TSPAN4, MEST, TM4SF1, LRRFIP1, STX11, TGM1, SPATA13, IER3, SLC44A3, SLC7A1, AHNAK, AHNAK2, H19, BTG3, CHAC1 |
| Genes induced in astrocytes after LPS treatment | |
| ECM binding/modification/adhesion | CD44, GALNTL2, SULF2, CRISPLD2, DCN, THBS2, LRG1, GGTA1, AMIGO2, FBL5, ICAM1, NFASC, SORBS1, CHI3L1 |
| Unclassified immune response | CD14, SRGN, S1PR3, TLR2, OASL2, MPA2L, SAA3.ZC3HAV1, TRIM30A, LCN2, TGTP1, IRGM1, IRGM1, TNFAIP2, PTX3 |
| Antigen processing and presentation | TAPBP, TAPBPL, B2M, H2-D1, H2-K1, H2-Q6, H2-T10, H2-T23, PMSB8, PSMB9, PROCR |
| Transporters/channels | STEAP4, CP, KCTD1, SLC22A4, SLC39A14, SLC1A5, SLC10A6 |
| Cytokines and cytokine receptors | CXCL1, CXCL10, CXCL2, SPP1, IL1R1, IL13RA, OSMR |
| Response to interferon beta | IFI202B, IFI44, IFITM3, IGTP, IIGP1, GBP2, GBP3 |
| Cell-cycle arrest/programmed cell death | BCL3, CDKN1A, PARP14, XAF1, NEK6 |
| Complement pathway | C1RB, C1RA, C3, SERPING1, C4B, C1S |
| Filament proteins/binding | GFAP, VIM, TAGLN2, SYNPO |
| Peptidase inhibitors | CD109, A2M, SERPINA3N, TIMP1 |
| Protein folding response to stress | FKBP5, HSP1, HSPB6 |
| Signal transduction | SPHKAP, MAP3K6, RHOJ |
| Neuron development | GAP43, OLFM1, SEMA4C |
| Response to oxidative stress | GPX3, GSR |
| Miscellaneous | ACSL5, HPGD, ASPG, CELA1, USP18, CPNE8, LY6E, UGT1A1, ENDOU, PLIN4, TSPO, TGM1, NT5E, ANGPT1, TGM2, S100A10, TSPAN4, SLC43A3, IER3 |
Reactive astrogliosis genes more than fourfold induced by MCAO and LPS and grouped by gene ontology. Bold is used for emphasis.