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. Author manuscript; available in PMC: 2012 Oct 24.

Published in final edited form as: J Org Chem. 2009 Mar 6;74(5):1897–1916. doi: 10.1021/jo802269q

Table 4.

Cell-Growth Inhibition of Bistramide Stereochemical Analogs 1.1–1.36 Against UO-31 and SF-295 Cancer Cell Lines.

compound	UO-31 (IC₅₀ ± SEM µM)	SF-295 (IC₅₀ ± SEM µM)

1.1	0.071 ± 0.01	0.47 ± 0.2

1.2	5.9± 1.1	_^a
1.3	45 ± 8	78.8 ± 4
1.4	4.6 ± 0.7	4.7 ± 2
1.5	0.62± 0.03	2 ± 0
1.6	14.8 ± 4.5	_^a
1.7	45.3 ± 0.5	76.5
1.8	15.9 ± 7.3	_^a
1.9	0.32 ± 0.02	0.2 ± 0.0
1.10	15.6 ± 4.5	_^a
1.11	17.1 ± 2.2	_^a
1.12	2.8 ± 0.4	_^a
1.13	1.9 ± 0.2	~2.4^b
1.14	7.8 ± 3.5	77.5 ± 4
1.15	18.2 ± 5.8	_^a
1.16	11 ± 1.4	~96^b
1.17	0.33 ± 0.02	3.5
1.18	13.9 ± 5.3	_^a
1.19	44.7 ± 9.7	_^a
1.20	14.5 ± 5	~14^b

1.21	0.044 ± 0.017	~3.8^b

1.22	44.7 ± 20.7	_^a
1.23	6.2 ± 0.5	17.1 ± 6
1.24	45.1 ± 30.8	75.2
1.25	5.7 ± 0.7	~34^b
1.26	0.82 ± 0.07	~30^b
1.27	17.4 ± 6.4	_^a
1.28	15 ± 9.9	_^a
1.29	0.81 ± 0.08	~20^b
1.30	14.9 ± 0.4	_^a
1.31	14.6 ± 10.2	_^a
1.32	5.3 ± 1.4	_^a

1.33	0.33 ± 0.04	0.34 ± 0.1

1.34	12 ± 1.7	_^a
1.35	15.4 ± 9.3	_^a
1.36	2.2 ± 0.3	~16^b

^a

Compounds were not tested.

^b

Estimated IC₅₀ value.