Table 17.
Age-Adjusted and Age-Specific Incidence Rates† for Childhood Brain and Central Nervous System Tumors: Malignant and Non-Malignant by International Classification of Childhood Cancer (ICCC), CBTRUS Statistical Report: NPCR and SEER, 2005–2009
| ICCC Category | 0-19‡ years |
0-14‡ years |
< 1 year |
1-4 years |
5-9 years |
10-14 years |
15-19 years |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Count | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | |
| II Lymphomas and reticuloendothelial neoplasms | 69 | 0.02 | (0.01-0.02) | 0.01 | (0.01-0.02) | – | – | – | – | 0.02 | (0.01-0.03) | 0.02 | (0.01-0.03) | 0.03 | (0.02-0.04) |
| III CNS and misc intracranial and intraspinal neoplasms | 17,654 | 4.38 | (4.31-4.44) | 4.32 | (4.25-4.40) | 4.53 | (4.24-4.83) | 4.82 | (4.67-4.97) | 4.21 | (4.08-4.34) | 4.03 | (3.91-4.16) | 4.53 | (4.41-4.67) |
| III(a) Ependymomas and choroid plexus tumor | 1,506 | 0.37 | (0.35-0.39) | 0.39 | (0.37-0.41) | 0.93 | (0.80-1.07) | 0.59 | (0.54-0.64) | 0.27 | (0.24-0.31) | 0.25 | (0.22-0.29) | 0.31 | (0.28-0.35) |
| III(b) Astrocytomas | 6,277 | 1.56 | (1.52-1.60) | 1.66 | (1.61-1.70) | 1.25 | (1.10-1.41) | 1.92 | (1.83-2.02) | 1.61 | (1.53-1.69) | 1.58 | (1.50-1.66) | 1.27 | (1.21-1.34) |
| III(c) Intracranial and intraspinal embryonal tumors | 2,408 | 0.60 | (0.57-0.62) | 0.72 | (0.69-0.75) | 1.19 | (1.04-1.35) | 1.04 | (0.97-1.11) | 0.73 | (0.67-0.78) | 0.37 | (0.34-0.41) | 0.23 | (0.21-0.27) |
| III(d) Other gliomas | 2,135 | 0.53 | (0.51-0.56) | 0.58 | (0.55-0.61) | 0.26 | (0.20-0.34) | 0.61 | (0.56-0.67) | 0.70 | (0.65-0.76) | 0.49 | (0.44-0.53) | 0.40 | (0.37-0.44) |
| III(e) Other specified intracranial and intraspinal neoplasms | 4,602 | 1.14 | (1.11-1.17) | 0.82 | (0.79-0.86) | 0.61 | (0.51-0.73) | 0.51 | (0.47-0.57) | 0.76 | (0.70-0.81) | 1.17 | (1.10-1.24) | 2.08 | (2.00-2.17) |
| III(f) Unspecified intracranial and intraspinal neoplasms | 726 | 0.18 | (0.17-0.19) | 0.16 | (0.15-0.18) | 0.29 | (0.22-0.38) | 0.14 | (0.12-0.17) | 0.14 | (0.12-0.16) | 0.18 | (0.15-0.21) | 0.23 | (0.20-0.26) |
| IV Neuroblastoma and other peripheral nervous cell tumors | 206 | 0.05 | (0.04-0.06) | 0.06 | (0.05-0.07) | 0.28 | (0.21-0.37) | 0.09 | (0.07-0.11) | 0.03 | (0.02-0.04) | 0.02 | (0.02-0.04) | 0.03 | (0.02-0.04) |
| IX Soft tissue and other extraosseous sarcomas | 1,667 | 0.41 | (0.39-0.43) | 0.35 | (0.33-0.37) | 0.56 | (0.46-0.67) | 0.33 | (0.29-0.37) | 0.28 | (0.25-0.32) | 0.39 | (0.35-0.43) | 0.60 | (0.55-0.65) |
| X(a) Intracranial & intraspinal germ cell tumors | 823 | 0.20 | (0.19-0.22) | 0.18 | (0.16-0.19) | 0.38 | (0.30-0.48) | 0.06 | (0.05-0.08) | 0.14 | (0.11-0.16) | 0.27 | (0.23-0.30) | 0.29 | (0.26-0.32) |
| All other categories | 290 | 0.07 | (0.06-0.08) | 0.04 | (0.04-0.05) | – | – | 0.04 | (0.02-0.05) | 0.03 | (0.02-0.05) | 0.06 | (0.05-0.08) | 0.15 | (0.13-0.18) |
| Total§ | 20,709 | 5.13 | (5.06-5.20) | 4.97 | (4.89-5.05) | 5.82 | (5.49-6.16) | 5.33 | (5.18-5.50) | 4.70 | (4.56-4.84) | 4.79 | (4.65-4.93) | 5.63 | (5.49-5.77) |
† Rates are per 100,000 and are ‡age adjusted to the 2000 U.S. standard population.
§ Refers to all brain tumors including histologies not presented in this table.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific ICCC category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: ICCC, International Classification of Childhood Cancer; CBTRUS, Central Brain Tumor Registry of the United States; NPCR, CDC's National Program of Cancer Registries; SEER, NCI's Surveillance, Epidemiology and End Results program; CI, confidence interval.