Table 4.

Cox OS analysis of biological variables’ prognostic effect

	Univariate Analysis			Multivariate Analysis
	HR	95% CI	P (2–sided Wald test)	HR	95% CI	P (2–sided Wald test)
1q gain (FISH)			0.554			0.202
Yes vs no	1.4	(0.5, 4.4)		2.0	(0.7, 5.8)
Nucleolin (IHC, % positive cells)			0.130			0.539
>50% vs ≤50%	2.1	(0.8, 5.6)		1.3	(0.6, 2.6)
EGFR (IHC)			0.340			0.714
Low vs strong	1.7	(0.6, 5.2)		1.2	(0.5, 2.5)
EGFR (mRNA)*			0.328			0.377
10.1 vs 5.1	1.6	(0.9, 2.8)		1.4	(0.8, 2.4)
32.7 vs 5.1	3.2	(0.7, 14.6)		2.6	(0.7, 9.8)
PROM1 (mRNA)*			0.993			0.967
53.5 vs 26.8	1.0	(0.5, 1.9)		0.9	(0.5, 1.9)
80.9 vs 26.8	1.0	(0.4, 2.3)		0.9	(0.4, 2.2)
HTERT (mRNA)*			0.024			0.011
6.2 vs 1.2	1.5	(1.1, 2.1)		1.7	(1.2, 2.3)
33.5 vs 1.2	7.1	(1.7, 29.2)		9.9	(2.2, 44.3)

*The 3 values are the quartiles of the variable distribution.