Skip to main content
. 2012 Sep 11;24(9):3805–3822. doi: 10.1105/tpc.112.098624

Table 1. Iron Metabolism-Related Genes Repressed by HapX Orthologs under Iron Starvation.

Gene Gene Product Wild Type ± Fe, log2 Wild Type/hapx −Fe, log2 Af Ca Sp Sc
FOXG_02862 Copper-resistance protein Crd2 3.93 −2.44 x
FOXG_06292 3-isopropylmalate dehydratase (Ile/Leu/Val biosynthesis) 3.17 −4.09 x x x x
FOXG_15294 Mycelial catalase Cat2 (heme) 3.10 −1.84
FOXG_04395 Dihydroxy acid dehydratase (Ile/Val biosynthesis) 3.07 −1.56 x x x x
FOXG_04047 Vacuolar iron transporter Ccc1 2.74 −2.79 x x x
FOXG_10653 Pyridine nucleotide-disulphide oxidoreductase 2.71 −1.62 x x
FOXG_05207 Aconitate hydratase, mitochondrial 2.54 −2.06
FOXG_10442 Nitrite/sulfite reductase ferredoxin-like half domain 2.49 −2.37
FOXG_04849 Cytochrome P450 monooxygenase 2.39 −1.61
FOXG_09278 Succinate dehydrogenase iron-sulfur protein; TCA cycle 2.37 −1.21 x x x
FOXG_11281 NADH-dependent glutamate synthase (GLT1) 2.32 −2.22 x x x x
FOXG_12892 lysF, Aconitase family (aconitate hydratase, Lys biosynthesis)a 2.30 −1.94 x x x
FOXG_12260 Peroxidase; catalase/peroxidase HPI 2.27 −1.48
FOXG_01544 Succinate dehydrogenase, flavoprotein subunit; TCA cycle 2.24 −1.25 x x x
FOXG_01159 Homocitrate synthase (Lys biosynthesis) 2.21 −1.00 x
FOXG_09472 Cytochrome P450 2.20 −1.08
FOXG_05118 Acyl-CoA dehydrogenase 1.84 −1.05
FOXG_03713 acoA, Aconitase family (aconitate hydratase), TCA cyclea 1.73 −1.41 x x x x
FOXG_08910 Cytochrome P450 monooxygenase 1.63 −1.97
FOXG_00142 Cytochrome c peroxidase 1.54 −1.33 x x
FOXG_06266 Siderophore transcription factor SreAa 1.23 −1.60 x x x
FOXG_06399 FMN-dependent dehydrogenase 1.17 −2.22
FOXG_12815 cycA, Cytochrome ca 1.12 −1.49 x x x x
FOXG_01103 Hemerythrin HHE cation binding domain-containing protein 1.06 −1.22

F. oxysporum genes that fulfill the following criteria in microarray-based transcriptional profiling: (1) More than twofold downregulated in the wild type under steady state iron starvation versus iron sufficiency (Wild Type ± Fe) and (2) more than twofold upregulated during steady state iron-starved growth in ΔhapX compared with the wild type (Wild Type/hapx − Fe). Genes are ranked based on the level of upregulation in the Wild Type ± Fe condition. The x indicates genes previously identified to be similarly regulated by the HapX orthologs in A. fumigatus (Af; Schrettl et al., 2010), C. albicans (Ca; Chen et al., 2011), and S. pombe (Sp; Mercier et al., 2008) or by Cth1 and Cth2 in S. cerevisiae (Sc; Puig et al., 2008).

a

Genes whose differential expression was confirmed separately by real-time RT-PCR.