Table 2. Putative Virulence-Related Genes Induced by Iron Starvation in a HapX-Dependent Manner.

Gene	Gene Product	Wild Type ± Fe, log2	Wild Type/hapX − Fe, log2	SignalP	THMM
FOXG_04016	Hypersensitive response–inducing protein	−3.54	1.09	x
FOXG_10677	PTH11-like integral membrane protein	−2.30	1.64		x
FOXG_16469	PTH11-like integral membrane protein	−1.93	1.07	x	x
FOXG_15833	Aspartyl protease	−1.49	1.50	x	x
FOXG_09759	Endo-1,3-beta-glucanase	−1.49	1.04	x
FOXG_11325	Aspartyl protease	−1.20	1.02	x
FOXG_10097	Aspartyl protease	−1.17	1.25	x
FOXG_10728	Pectate lyase	−1.08	1.23	x
FOXG_09366	ABC transporter	−1.08	1.19		x
FOXG_16838	Endoglucanase	−1.06	1.19	x
FOXG_16398	SIX3	−1.05	1.19

Putative virulence-related genes of F. oxysporum are shown that fulfill the following criteria in microarray-based transcriptional profiling: (1) more than twofold upregulated in the wild type under steady state iron starvation versus iron sufficiency (Wild Type ± Fe) and (2) more than twofold downregulated during steady state iron-starved growth in ΔhapX compared with the wild type (Wild Type/hapx − Fe). Genes are ranked based on the level of downregulation in the Wild Type ± Fe condition. Genes predicted to encode a signal peptide and/or transmembrane domain are marked with an x in the columns SignalP and THMM, respectively.