Table 4.

Genes specifically or differentially regulated by (A) low dose or (B) high dose risedronate with 24 hr treatment.

A
Symbol	Description	Fold	P value
	Signaling Array
Selp	Selectin, platelet	4.7	0.003
Cdh1	Cadherin 1	3.1	0.002
Odc1	Ornithine decarboxylase 1	2.1	0.006
	Osteogenesis Array
Bmp7	Bone morphogenetic protein 7	4.5	0.02
Smad2	MAD homolog 2 (Drosophila)	0.5	0.04
Mmp2	Matrix metallopeptidase 2	0.2	0.02
Cdh11	Cadherin 11	0.2	0.02
Enam	Enamelin	0.1	0.02

B
Symbol	Description	Fold	P value
	Signaling Array
Egr1	Early growth response 1	27.3	0.01
Faslg	Fas ligand (TNF superfamily, member 6)	9.0	0.00009
Ptgs2	Prostaglandin-endoperoxide synthase 2	5.0	0.003
Fasn	Fatty acid synthase	4.1	0.02
Cdkn1a	Cyclin-dependent kinase inhibitor 1A	4.1	0.03
Prkce	Protein kinase C, epsilon	3.9	0.04
Brca1	Breast cancer 1	3.9	0.01
Jun	Jun oncogene	3.5	0.02
Vegfa	Vascular endothelial growth factor A	3.0	0.04
Hoxa1	Homeo box A1	2.8	0.05
Cdk2	Cyclin dependent kinase 2	2.8	0.05
Bcl2l1	Bcl2-like 1	2.7	0.04
Hspb1	Heat shock 27kDa protein 1	2.7	0.02
Tcf7	Transcription factor 7, T-cell specific (predicted)	2.3	0.05
Gadd45a	Growth arrest and DNA-damage-inducible 45 alpha	2.3	0.01
Cdh1	Cadherin 1	0.4	0.003
	Osteogenesis Array
Mmp2	Matrix metallopeptidase 2	22.5	0.005
Col4a1	Procollagen, type IV, alpha 1	15.9	0.05
Bmp2	Bone morphogenetic protein 2	6.9	0.03
Icam1	Intercellular adhesion molecule 1	5.6	0.02
Dmp1	Dentin matrix protein 1	4.1	0.04
Scarb1	Scavenger receptor class B, member 1	3.7	0.02
Tgfb3	Transforming growth factor, beta 3	3.2	0.05
Ctsk	Cathepsin K	2.9	0.05
Twist1	Twist gene homolog 1 (Drosophila)	2.8	0.04
Smad3	MAD homolog 3 (Drosophila)	2.6	0.004
Bmp5	Bone morphogenetic protein 5 (predicted)	2.6	0.05
Col14a1	Procollagen, type XIV, alpha 1 (predicted)	2.1	0.02
Sox9	SRY-box containing gene 9	0.3	0.05
Bmpr1b	Bone morphogenetic protein receptor, type 1B	0.2	0.02