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. 2012 Oct 24;7(10):e46294. doi: 10.1371/journal.pone.0046294

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© 2012 Zhang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Structure of INZ synthetic analog 37. (B) Representative cell growth inhibition curves of INZ synthetic analogs 8, 30 and 37 in H460, H1299, HCT116^+/+ and HCT116^−/− cell lines. (C) ^a EC₅₀ of the selected INZ analogs represent the average of triplicates. The EC₅₀ values were determined by the two-parameter Hill equation where EC₅₀ and the Hill coefficient were allowed to refine while the maximal and minimal values remain fixed. ^b EC₉₀ values were calculated from the EC₅₀ and Hill slope by a web-based calculator: http://www.graphpad.com/quickcalcs/Ecanything1.cfm. ^c Not be able to be determined.