Skip to main content
. 2012 Oct 24;7(10):e47147. doi: 10.1371/journal.pone.0047147

Figure 6. Zinc and acidic pH activate AM546-treated K69C receptors to a greater degree than ATP alone.

Figure 6

A: Response of a K69C expressing oocyte to 1,000 µM ATP before and after AM546 (50 µM, 5 min). Traces were not baseline-corrected to emphasize the drop in holding current (vertical dashed line) after AM546 exposure. B: Effect of MTSEA challenge after treatment with AM546. The vertical dashed line indicates the drop in holding current after AM546. The horizontal dashed lines indicate the amplitude of the ATP response after MTSEA. C: Summary of a series of experiments as in B. The data are plotted as the responses after MTSEA normalized to the responses after AM546. The horizontal dashed line indicates 100% (i.e. no change in response after MTSEA). (N = 8). D: Effect of AM546 dosage (concentration * duration of exposure) on inward currents evoked by 1,000 µM ATP.