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Superimposition of the inserted domain of LipS (in red) with A) Est1E (2WTM, orange) and LJ0536 (3PF8, turquoise), B) human MGL (3PE6, purple) and C) EstD (3DKR, blue) and Est30 (1TQH, green). The core structure of LipS is indicated in grey and catalytic S126 in yellow. The core structures of LipS homologues are not shown for simplicity.
