Abstract
Blood specimens were collected over various periods of time from 30 abattoir workers with a clinical diagnosis of Q fever. All specimens were tested for complement-fixing antibodies and for specific immunoglobulin M (IgM) globulins to phase 1 and 2 Coxiella burnetii organisms by an immunofluorescence technique. All 22 patients with increasing levels of complement-fixing antibodies were shown to have generated specific IgM globulins, as did 4 patients with high convalescent titers but from whom "acute" specimens were not collected. Four individuals who did not show increasing levels of complement-fixing antibodies did not produce measurable levels of specific IgM. All patients with Q fever gave positive specific IgM results by 2 weeks after the onset of symptoms. IgM to phase 1 antigen persisted for 27 weeks in one patient, but IgM to phase 2 antigen was not detectable beyond 17 weeks. The estimation of Q fever-specific IgM has proved useful in confirming infection when only a "convalescent" blood specimen is available.
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Selected References
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- LENNETTE E. H., CLARK W. H., JENSEN F. W., TOOMB C. J. Q fever studies. XV. Development and persistence in man of complement-fixing and agglutinating antibodies to Coxiella burnetii. J Immunol. 1952 May;68(5):591–598. [PubMed] [Google Scholar]
- Murphy A. M., Field P. R. The persistence of complement-fixing antibodies to Q-fever (Coxiella burneti) after infection. Med J Aust. 1970 Jun 6;1(23):1148–1150. doi: 10.5694/j.1326-5377.1970.tb84481.x. [DOI] [PubMed] [Google Scholar]
- Murphy A. M., Magro L. IgM globulin response in Q fever (Coxiella burneti) infections. Pathology. 1980 Jul;12(3):391–396. doi: 10.3109/00313028009077101. [DOI] [PubMed] [Google Scholar]
- Peacock M. G., Fiset P., Ormsbee R. A., Wisseman C. L., Jr Antibody response in man following a small intradermal inoculation with Coxiella burnetii phase I vaccine. Acta Virol. 1979 Jan;23(1):73–81. [PubMed] [Google Scholar]