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. 2012 Oct 24;7(10):e47627. doi: 10.1371/journal.pone.0047627

Table 1. Simulation results under sparse cases with p = 100 and n = 100 based on 50 replications.

Inline graphic, q = 2 Inline graphic, q = 4
CC CS Ridge Lasso CC CS Ridge Lasso
Scenario1, s = 4 LR-test −5.89 −5.88 −4.99 −10.59 −4.71 −4.55 −4.75 −8.76
Cox-test −8.41 −8.26 −7.32 −13.80 −6.76 −7.06 −6.95 −11.73
Devi 66.63 45.62 −29.48 −76.92 75.34 56.30 −25.75 −60.50
c-index 0.772 0.768 0.752 0.859 0.750 0.751 0.750 0.825
Inline graphic Inline graphic / 0.25 74.54 7.06 / 0.28 68.81 6.59
Scenario2 LR-test −8.88 −9.35 −7.01 −12.39 −6.38 −6.74 −6.30 −11.40
Cox-test −12.16 −12.35 −9.64 −14.51 −9.27 −9.94 −8.77 −14.21
Devi −17.25 −26.02 −43.04 −95.39 −4.63 −11.32 −36.79 −84.14
c-index 0.828 0.833 0.790 0.879 0.785 0.790 0.770 0.864
Inline graphic / 0.30 37.88 6.90 / 0.30 50.91 6.17
Inline graphic, q = 5 Inline graphic, q = 10
CC CS Ridge Lasso CC CS Ridge Lasso
Scenario1, s = 4 LR-test −3.88 −4.31 −4.21 −6.64 −2.28 −2.45 −2.40 −1.90
Cox-test −6.18 −6.19 −6.04 −9.47 −3.03 −3.03 −3.01 −2.86
Devi 80.59 56.87 −21.44 −43.22 145.95 97.88 −9.28 −7.85
c-index 0.725 0.722 0.722 0.790 0.659 0.656 0.652 0.649
Inline graphic / 0.28 79.85 6.89 / 0.275 101.77 8.44
Scenario2 LR-test −13.71 −13.69 −11.38 −14.52 −9.67 −9.34 −8.86 −9.65
Cox-test −15.18 −15.22 −14.04 −15.48 −12.68 −12.65 −11.34 −12.24
Devi −23.91 −34.13 −77.63 −107.14 8.563 −0.559 −55.62 −67.93
c-index 0.886 0.885 0.862 0.889 0.843 0.835 0.822 0.838
Inline graphic / 0.33 33.34 6.66 / 0.29 47.22 6.86

NOTE: For Scenario 1, each informative covariate is correlated with s non-informative covariates. For Scenario 2, the covariates for the right panel have two gene pathways and those for the left panel have one gene pathway. In each setting, q is the number of informative covariates (covariates with non-zero coefficients).