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Cumulative incidence of diabetic end-stage kidney disease (ESKD) in Pima Indians with type 2 diabetes. At any attained age, participants with youth-onset type 2 diabetes, defi ned as onset of diabetes before 20 years of age, have a longer duration of diabetes, and thus a higher risk of diabetic ESKD than those with older-onset diabetes mellitus. (Adapted from Pavkov et al. [34•].)
