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. 2012 Oct 10;32(41):14355–14363. doi: 10.1523/JNEUROSCI.2156-12.2012

Figure 2.

Figure 2.

MeCP2 S421A KI mice exhibit increased sensitivity to environmental stressors. a, MeCP2 KI mice and their WT littermates were injected with Veh 30 min before the tail-suspension test, and the amount of time immobile each minute of the 6 min test was recorded. b, MeCP2 KI mice and their WT littermates were injected with either Veh or imipramine (10 or 20 mg/kg) 30 min before the forced swim. Total time immobile and treading over the 6 min test was recorded. c, KI mice and WT littermates were tested for their preference for increasing concentrations of sucrose in a two-bottle choice test. n = 6–7 mice per group for a, n = 4–14 mice per group for b, and n = 7–10 mice per group for c. For a, *p < 0.05 compared with WT at each time point. For b, *p < 0.05 Veh compared with imipramine at 10 or 20 mg/kg within each genotype, and #p < 0.05 WT Veh compared with KI Veh.