TABLE 1.

NETWORKS ASSOCIATED WITH DIFFERENTIALLY METHYLATED GENES IN IDIOPATHIC PULMONARY FIBROSIS VERSUS NORMAL TISSUE

Score	Focus Molecules*	Top Functions
46	19	Humoral immune response, protein synthesis, infectious disease
28	13	Energy production, lipid metabolism, small-molecule biochemistry
20	10	Cellular assembly and organization, cellular compromise, nervous system development and function
3	1	Molecular transport, protein synthesis, protein trafficking
3	1	DNA replication, recombination, and repair; gene expression; genetic disorder
3	1	Cellular growth and proliferation, dermatological diseases and conditions, genetic disorder
2	1	Protein trafficking, connective tissue disorders, immunological disease
2	1	DNA replication, recombination, and repair; digestive system development and function; drug metabolism

^*For a list of molecules, see Table E3. The genes used in the network analysis were selected on the basis of a false positive discovery rate (FDR) ≤ 0.05 (see the online supplement for detail).