TABLE 3.
Haplotype | Frequency in PGD | Frequency in Non-PGD | OR | P Value |
Block 1 | ||||
GA | 0.59 | 0.49 | 1.3 | 0.048 |
AT | 0.47 | 0.50 | 0.8 | 0.04 |
GT | 0.01 | 0.01 | 1.1 | 0.8 |
Block 2 | ||||
CCTCC | 0.46 | 0.49 | 0.7 | 0.02 |
ATGCC | 0.38 | 0.36 | 1.3 | 0.03 |
CCTTT | 0.05 | 0.05 | 0.7 | 0.3 |
ATTCC | 0.05 | 0.04 | 1.8 | 0.05 |
CTGCC | 0.02 | 0.03 | 0.7 | 0.5 |
CTTCC | 0.02 | 0.02 | 1.4 | 0.4 |
Definition of abbreviations: OR = odds ratio; PGD = primary graft dysfunction.
ORs for PGD for individual haplotypes are based on logistic regression controlling for population stratification, using principal component analysis, use of cardiopulmonary bypass, and preoperative pulmonary diagnosis. The alleles encoded by the identified risk single-nucleotide polymorphisms, rs2120243 and rs2305619, are the first two alleles in block 2; the risk alleles are A and T, respectively.