TABLE 3.

HAPLOTYPE ANALYSIS FOR ASSOCIATION WITH PRIMARY GRAFT DYSFUNCTION

Haplotype	Frequency in PGD	Frequency in Non-PGD	OR	P Value
Block 1
GA	0.59	0.49	1.3	0.048
AT	0.47	0.50	0.8	0.04
GT	0.01	0.01	1.1	0.8
Block 2
CCTCC	0.46	0.49	0.7	0.02
ATGCC	0.38	0.36	1.3	0.03
CCTTT	0.05	0.05	0.7	0.3
ATTCC	0.05	0.04	1.8	0.05
CTGCC	0.02	0.03	0.7	0.5
CTTCC	0.02	0.02	1.4	0.4

Definition of abbreviations: OR = odds ratio; PGD = primary graft dysfunction.

ORs for PGD for individual haplotypes are based on logistic regression controlling for population stratification, using principal component analysis, use of cardiopulmonary bypass, and preoperative pulmonary diagnosis. The alleles encoded by the identified risk single-nucleotide polymorphisms, rs2120243 and rs2305619, are the first two alleles in block 2; the risk alleles are A and T, respectively.