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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Gastroenterology. 2012 Aug 8;143(5):1319–1329.e11. doi: 10.1053/j.gastro.2012.07.115

Figure 1. Metabolism is reprogrammed during HSC transdifferentiation.

Figure 1

Primary HSCs were cultured for 7 days. Culture-related changes in A) mRNA and B, C) protein expression of glycolytic enzymes, hexokinase (HK2), phosphofructokinase (PFKP), and pyruvate kinase M2 (PKM2). Related changes in B) the MF marker (αSMA), D) glucose transporter (GLUT1), lactate transporter (MCT4), E) gluconeogenesis-related genes, phosphoenolpyruvate carboxykinase (PCK1) and fructose bisphosphatase (FBP1), and F) intracellular lactate. *P<.05; **P<.01; ***P<.001 versus day 0.