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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Gastroenterology. 2012 Aug 8;143(5):1319–1329.e11. doi: 10.1053/j.gastro.2012.07.115

Figure 4. Metabolic reprogramming of HSCs is a conserved response to liver injury.

Figure 4

Mice injected once with CCl4 (A, B), fed methionine-choline deficient (MCD) diets for 8 weeks (C, D) or subjected to bile duct ligation (BDL, E, F) for 2 weeks to cause liver damage. Changes in glycolysis-related gene/protein expression were evaluated by QRT-PCR (A, C, E), immunoblot and immunohistochemistry (B, D, F) and correlated with changes in MF marker expression (B, D, F and Supplementary Fig.3). *P <.05; **P<.01; ***P<.001 versus control.