Fig. 5.

Reduction of kainic acid (KA)-induced seizure severity by AM6701 and AM6702. Seizures were initiated in rats with an intraperitoneal injection of 9.8 mg/kg KA. Immediately following the KA administration, animals were injected with vehicle (n = 16) or 5 mg/kg AM6701 or AM6702 (n = 6–8). No-insult control rats received 2 vehicle injections (n = 13). Seizures scores were tabulated by blinded raters for a 4-h period following the injections, and the mean scores ± SEM are shown. Analysis of variance, p < 0.0001; post hoc test compared to KA only group: ***p < 0.001