Fig. 9.

Comparison of effects on GluA1 versus pGluA1-Ser-845. Percent change in the 2 species is shown for the kainic acid (KA) insult, AM6701-mediated excitotoxic protection, the change due to AM6702, and the AM6701 effect as a percent change in the immunoreactivity levels of the AM6702 group (a). KA plus AM6701 rats were plotted against the KA plus AM6702 group in rank order of immunoblot levels for GluA1 (open circles) and pGluA1-Ser-845 (closed circles) in hippocampal homogenates (b). Linear regression was applied to the 2 species (r = 0.975 and r = 0.955, respectively; p < 0.001), and the slopes were found to be different (p = 0.02)