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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Circ Heart Fail. 2012 Aug 16;5(5):602–609. doi: 10.1161/CIRCHEARTFAILURE.112.966960

Table 3.

Uni- and multivariate Cox proportional hazard models for different renal measures as predictors of MACE.

Log-transformed COX PROPORTIONAL HAZARD
UNADJUSTED MODEL 1§ MODEL 2
Hazard Ratio# P-value Hazard Ratio# P-value Hazard Ratio# P-value
Urea 1.40 (1.22–1.59) <0.0001 1.25 (1.09–1.42) 0.0016 1.14 (0.96–1.28) 0.17
Creatinine 1.34 (1.21–1.48) <0.0001 1.22 (1.09–1.35) 0.0008 1.17 (1.03–1.32) 0.015
eGFRMDRD 0.72 (0.65–0.80) <0.0001 0.80 (0.72–0.90) 0.0002 0.85 (0.75–0.96) 0.012
Cystatin C 1.45 (1.30–1.60) <0.0001 1.29 (1.15–1.44) <0.0001 1.20 (1.05–1.36) 0.0085
eGFRCysC 0.69 (0.62–0.77) <0.0001 0.77 (0.68–0.87) <0.0001 0.82 (0.73–0.94) 0.006
eGFRsCr+CysC 0.70 (0.63–0.78) <0.0001 0.78 (0.70–0.88) <0.0001 0.83 (0.73–0.94) 0.006

Abbreviations as in Table 1. P-value for log(BNP) <0.001 in every model.

§

Model 1 is adjusted for log-transformed BNP

Model 2 is further adjusted for age, BMI, history of coronary artery disease, history of diabetes mellitus, hemoglobin, and hsCRP.

#

Hazard ratios are per 1-standard deviation (Urea 12.7, Creatinine 0.89, eGFRMDRD 26.2, Cystatin C 0.73, eGFRCysC 23.7, eGFRsCr+CysC 24.8)