Table 2.
Structure/Macrosystem | Subregion | Lever presses/% Fos + CTb cells |
Beam breaks/% Fos + CTb cells |
||
---|---|---|---|---|---|
All cocaine seeking | CS + Reinst. only | Horizontal locomotion | Vertical locomotion | ||
Extended amygdala | AA | 0.63** | 0.07 | −0.37 | 0.22 |
DBNST | 0.46* | −0.11 | 0.57 | 0.65 | |
VBNST | 0.74** | 0.58 | 0.60 | 0.65 | |
IPAC | −0.03 | −0.28 | 0.03 | 0.45 | |
MeA | 0.29 | 0.48 | 0.01 | 0.83* | |
CeA | 0.44 | 0.37 | 0.61 | −0.58 | |
SLEA | 0.36 | −0.57 | 0.45 | 0.73 | |
Stia | 0.43 | 0.53 | 0.01 | 0.01 | |
Accumbens core | Core | 0.51* | −0.08 | 0.19 | −0.18 |
Accumbens shell | Rostral Pole | 0.08 | −0.44 | 0.01 | 0.29 |
DM-Rostral | 0.28 | −0.50 | 0.44 | 0.29 | |
VM-Rostral | 0.20 | 0.18 | 0.58 | −0.79 | |
DM-Caudal | 0.42 | −0.41 | 0.40 | 0.30 | |
VM-Caudal | 0.88*** | 0.80* | 0.63 | 0.41 | |
Lateral | 0.77*** | 0.43 | 0.04 | −0.77 | |
Pallidum | VP | 0.63** | 0.91 | 0.58 | 0.54 |
Septum | LS | 0.57** | −0.22 | 0.42 | 0.68 |
MS | 0.55** | 0.41 | 0.31 | 0.87* | |
Cortex-like amygdala | BLA | −0.25 | −0.95** | −0.18 | 0.69 |
BMA | 0.30 | −0.10 | −0.59 | 0.19 | |
Prefrontal cortex | CG1 | −0.11 | −0.74* | 0.56 | 0.27 |
CG2 | −0.23 | −0.09 | 0.20 | −0.48 | |
PLC | 0.26 | 0.42 | 0.05 | 0.27 | |
ILC | −0.25 | −0.42 | 0.64 | 0.05 | |
DP | 0.45 | 0.43 | 0.46 | 0.30 | |
DTT | 0.40 | 0.01 | 0.30 | 0.06 | |
NavN | 0.44 | 0.18 | 0.25 | −0.26 | |
MOFC | 0.11 | −0.19 | −0.35 | 0.90* | |
DLOFC | −0.19 | −0.15 | 0.98** | 0.35 | |
LOFC | 0.27 | 0.14 | −0.32 | 0.10 | |
VOFC | 0.34 | 0.26 | −0.60 | 0.34 | |
DEn | 0.45 | 0.05 | 0.78 | 0.11 | |
Claust | −0.16 | −0.78* | 0.71 | 0.36 | |
Hypothalamus | AH | 0.10 | −0.69 | −0.69 | 0.46 |
PH | 0.28 | 0.32 | −0.41 | 0.23 | |
LH | 0.74*** | 0.06 | 0.11 | 0.49 | |
VMLH | 0.39 | 0.38 | −0.40 | 0.91* | |
DMH | 0.38 | 0.59 | −0.16 | 0.90* | |
VMH | 0.46 | 0.57 | 0.51 | −0.08 | |
PFA | 0.49* | −0.14 | −0.40 | 0.59 | |
LPO | 0.38 | −0.34 | 0.32 | 0.48 | |
MPO | 0.47 | 0.00 | 0.00 | 0.65 | |
PVH | 0.32 | −0.72 | 0.38 | 0.54 | |
pmamm | 0.18 | 0.52 | 0.16 | 0.94* | |
Habenula | MHb | −0.36 | −0.71 | 0.53 | −0.56 |
LHb | −0.44 | 0.03 | 0.76 | 0.13 | |
Raphe nucleus | Dorsal | −0.12 | −0.19 | −0.05 | 0.21 |
Medial | −0.28 | 0.32 | −0.37 | −0.72 | |
Paramedial | −0.01 | 0.10 | −0.16 | −0.16 | |
Tegmentum | PPT-Rostral | 0.07 | −0.11 | 0.51 | −0.29 |
PPT-Caudal | 0.20 | −0.42 | 0.39 | 0.54 | |
RMTg/tVTA | −0.48* | 0.16 | 0.71 | −0.45 | |
SC | −0.20 | −0.12 | 0.12 | 0.10 |
Correlations of Fos in VTA afferent neurons with cocaine-seeking behavior, cued reinstatement behavior, horizontal locomotion, and vertical locomotion are shown. “All cocaine seeking” behavior is defined as active lever presses in the first 30 min of CS + reinstatement, CS− control, and extinction control sessions (n = 19). “CS + Reinstatement Only” (Reinst. Only) behavior is defined as cue-triggered reinstatement within the CS + reinstatement group alone (n = 8). Horizontal and vertical locomotion was measured in the locomotor control group (n = 6). Significant correlations are designated as *p < 0.05, **p < 0.01, ***p < 0.001.