Table 1.
Patient and tumour characteristics by histopathological subtypes
| |
SCC |
ASC |
AC |
Pvalue |
|---|---|---|---|---|
| n = 79 | n = 38 | n = 75 | ||
|
Age (years), mean ± sd |
49.8 ± 14.5 |
43.0 ± 11.7 |
44.7 ± 13.3 |
0.014 |
|
(95% CI for mean) |
(46.6-53.1) |
(39.1-46.8) |
(41.6-47.7) |
|
|
FIGO stage I, n (%) |
64 (81) |
34 (89) |
67 (89) |
0.260 |
|
FIGO stage II, n (%) |
15 (19) |
4 (11) |
8 (11) |
|
|
High-risk HPV positive, n (%) |
75 (95) |
37 (97) |
64 (85) |
0.036 |
|
- HPV 16 |
51 (68) |
19 (51) |
28 (44) |
0.003 |
|
- HPV 18 |
13 (17) |
12 (32) |
28 (44) |
|
|
- Other |
11 (15) |
6 (16) |
8 (12) |
|
|
Tumour size ≥ 40 mm, n (%) |
31 (41) |
16 (42) |
11 (16) |
0.001 |
|
Infiltration depth ≥ 15 mm, n (%) |
39 (51) |
13 (34) |
17 (24) |
0.003 |
|
Positive LVSI, n (%) |
47 (60) |
19 (53) |
23 (38) |
0.037 |
|
Positive resection margins, n (%) |
22 (28) |
4 (11) |
17 (23) |
0.109 |
|
Positive parametria, n (%) |
8 (10) |
4 (11) |
4 (5) |
0.483 |
|
Positive lymph nodes, n (%) |
27 (34) |
9 (24) |
15 (20) |
0.125 |
|
Adjuvant radiotherapy, n (%) |
48 (61) |
18 (47) |
30 (40) |
0.034 |
|
Follow-up time (months), mean ± sd |
199.4 ± 11.9 |
186.3 ± 16.6 |
201.9 ± 11.0 |
0.782 |
|
(95% CI for mean) |
(176.1-222.6) |
(153.9-218.8) |
(180.3-223.5) |
|
|
Recurrence-free time (months), mean ± sd |
184.2 ± 12.4 |
168.3 ± 17.6 |
148.2 ± 10.5 |
0.977 |
|
(95% CI for mean) |
(160.0-208.4) |
(133.8-202.8) |
(127.5-168.8) |
|
|
Death, all causes, n (%) |
34 (43) |
12 (32) |
22 (29) |
0.177 |
|
Death by tumour, n (%) |
19 (24) |
10 (26) |
16 (21) |
0.828 |
| Recurrent disease, n (%) | 21 (27) | 10 (26) | 19 (24) | 0.984 |
P values were calculated using the Pearson Chi-square test for categorical data and one-way analysis of variance for numerical data. Total follow-up time and disease-free time were calculated by the Log Rank (Mantel-Cox) test for the histopathological subgroups separately. P values in bold type were considered statistically significant (P < 0.05). For nine, six, eighteen, and one cases the tumour size, depth of infiltration, LVSI (lymph-vascular space invasion), and tumour positivity of resection margins, respectively, could not be identified. SCC, cervical squamous cell carcinoma; ASC, cervical adenosquamous carcinoma; AC, cervical adenocarcinoma; FIGO, International Federation of Gynaecology and Obstetrics; HPV, human papillomavirus; CI, confidence interval.