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Characterization of the humanized mouse. (A) Spontaneous production of immunoglobulins by 16-week old “humanized” mice. Serum from a non-reconstituted NSG mouse was used as a negative control. (B) Production of the anti-HIB immunoglobulin 4 weeks after the third immunization with Act-HIB. (C) Human immune cells were found in the peritoneal cavity 72 hours after intraperitoneal injection of thioglycollate. All mature cell types, including T and B cells and macrophages were present.
