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TGFBI up-regulates expression of p53 and p21. (A) Mesothelioma and (B) breast tumor cell lines transfected with vector and TGFBI were synchronized in quiescence by serum starvation and induced to reenter the cell cycle by the addition of serum. Temporal expression of p53 and p21 in response to serum stimulation were assessed by Western blotting.
