Table 2.
Blood level measurements by BMI and blood pressure groups - categorical variables: frequencies (percents); continuous variables: mean (SD) or geometric mean [1st quartile, 3rd quartile]
| N-NBP (N = 111) |
N-HBP (N = 35) |
O-NBP (N = 103) |
O-HBP (N = 52) |
4- Group p-value† |
2- Group p-value† |
|
|---|---|---|---|---|---|---|
|
Fasting Glucose
(mg/dl) |
95.5 ( 8.5) | 96.4 ( 7.8) | 98.4 (13.5) | 97.4 ( 8.3) | 0.402 | 0.774 |
| Glucose 2 hr (mg/dl) | 1 12.3 (21.7) | 115.4 (22.9) | 123.1 (41.8) | 121.3 (23.1) | 0.090 | 0.410 |
|
Fasting Insulin
(uU/ml) ‡ |
5.1 [3.6, 7.2] | 5.7 [4.0, 7.3] | 10.6 [6.6, 16.9] | 13.2 [9.7, 17.4] | <.001 | <.001 |
| Insulin 2 hr (uU/ml) ‡ | 39.7 [26.4, 62.2] | 33.8 [19.5, 65.1] | 55.4 [34.9, 103] |
69.1 [42.8, 110] |
<.001 | 0.006 |
| HOMA (mg/dl) ‡ | 1.19 [0.84, 1.71] | 1.33 [0.91, 1.86] | 2.56 [1.57, | 3.17 [2.30, | <.001 | <.001 |
| 4.09] | 4.45] | |||||
| HDL (mg/dl) | 58.1 (12.0) | 57.0 (13.4) | 48.8 (11.3) | 45.3 ( 9.6) | <.001 | <.001 |
| LDL (mg/dl) | 85.0 (23.5) | 83.2 (25.1) | 91.2 (29.6) | 94.8 (27.1) | 0.151 | 0.166 |
| Triglycerides (mg/dl) ‡ | 5 4 . 4 [43.0, 69.0] | 60.7 [48.0, 76.0] | 66.2 [52.0, | 71.7 [56.5, | <.001 | 0.016 |
| 88.0] | 87.5] | |||||
|
Total Cholesterol
(mg/dl) |
155.0 (27.6) | 154.9 (31.2) | 154.7 (31.7) | 156.4 (31.1) | 1.000 | 0.818 |
| UAE (mg/gm creat) ‡ | 2.79 [1.21, 6.11] | 2.61 [1.13, 5.20] | 2.30 [0.93, | 2.27 [1.15, | 0.746 | 0.599 |
| 4.61] | 3.54] | |||||
| Adiponectin (ug/ml) ‡ | 6.8 [4.7, 11.1] | 6.4 [3.8, 12.2] | 4.6 [3.4, 7.1] | 4.8 [3.3, 7.2] | <.001 | 0.205 |
| IL6 (pg/ml) ‡ | 2.3 [1.7, 2.8] | 3.0 [2.1, 4.1] | 3.0 [2.2, 4.0] | 2.9 [2.1, 4.1] | 0.004 | 0.410 |
| PAI1 (ng/ml) | 44.5 (19.9) | 47.2 (23.6) | 71.7 (23.4) | 78.8 (31.2) | <.001 | <.001 |
| TNFα (pg/ml) ‡ | 8.2 [7.0, 9.4] | 8.3 [7.4, 8.9] | 8.0 [6.8, 9.5] | 8.2 [6.6, 9.0] | 0.979 | 0.937 |
|
TNFα Receptor
(Pg/ml) ‡ |
0.8 [0.6, 1.0] | 0.9 [0.7, 1.1] | 1.0 [0.8, 1.2] | 1.0 [0.8, 1.2] | 0.010 | 0.022 |
| hsCRP (mg/dl) ‡ | 0.4 [0.2, 0.7] | 0.4 [0.2, 1.0] | 1.4 [0.6, 3.5] | 1.4 [0.6, 3.1] | <.001 | <.001 |
| Metabolic Syndrome | 0 (0%) | 1 ( 3%) | 15( 15%) | 31 (60%) | <.001 | <.001 |
Fishers exact test (categorical) or ANOVA F-test (continuous): any groups different (4-group) and O-HBP vs. others combined (2-group). Adjustments made for multiple comparisons and false discovery rate.
Data natural log transformed: geometric means with [first quartile, third quartile] presented
UAE: creatinine-corrected urinary albumin excretion; N-NBP: non-obese normal BP; N-HBP: non-obese high BP; O-NBP: obese normal BP; O-HBP: obese normal BP;
Metabolic Syndrome: 3 or more of following: BMI Percentile > 95; SBP >120 or DBP >80; HDL <40 (males) or <50 (females); Triglycerides >110; Fasting glucose >110