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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Nutr Biochem. 2012 Jul 21;24(4):664–671. doi: 10.1016/j.jnutbio.2012.03.016

Fig. 5. Schematic diagram of DIM’s action in colorectal cancer cells.

Fig. 5

DIM increases an ATF4 transcriptional factor that selectively binds to the ATF site in the ATF3 promoter. This in turn results in the increased expression of ATF3. Increased ATF3 expression results in an increase of apoptosis in colorectal cancer cells.