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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Mucosal Immunol. 2012 Jun 13;5(6):681–690. doi: 10.1038/mi.2012.41

Figure 6.

Figure 6

GBP-1 acts to suppresses β-catenin/TCF signaling. A: SKCO15 cells were transiently transfected with a β-catenin/TCF responsive luciferase reporter construct (TOP) or a reporter in which the TCF responsive sites have been mutated (FOP, values = TOP-FOP). Cells were further treated with TNF-β/IFN-γ for 48hrs or transiently transfected with full length GBP-1 or the GBP-1 helical domain where indicated. Protein expression was confirmed by western blot (right panel), * indicates p< 0.05 by ANOVA. B. SKCO15 cells were transiently co-transfected with a β-catenin/TCF responsive luciferase reporter construct and GBP-1 or GBP-5 (values = TOP-FOP). Protein expression was confirmed by western blot (right panel), * indicates p< 0.05 by ANOVA.