Table 3.
Comparison of fast ionotropic and slow metabotropic receptors for ACh, GABA, glutamate and 5-HT with those proposed for ATP [Updated and reproduced from Burnstock (1996) with permission from John Wiley and Sons]
| Receptors | ||
|---|---|---|
| Neurotransmitter | Fast ionotropic (ligand-gated ion channels) | Slow metabotropic (G protein) |
| ACh | NICOTINIC | MUSCARINIC |
| Muscle type | M1 → M5 | |
| Neuronal type | ||
| GABA | GABA A | GABA B |
| GLUTAMATE | AMPA | mGlu1 |
| Kainate | ↓ | |
| NMDA | mGlu7 | |
| 5-HT | 5-HT3 | 5-HT1A-F 5-HT2A-C |
| 5-HT4 5-HT5A-B | ||
| 5-HT6 5-HT7 | ||
| ATP | P2X | P2Y |
| P2X1 → P2X7 | P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, P2Y14 | |