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. 2012 Sep;167(2):383–392. doi: 10.1111/j.1476-5381.2012.01973.x

Figure 1.

Figure 1

SEN1269 inhibits Aβ aggregation, protects cell viability against Aβ1–42-induced insults and binds to Aβ1–42. (A) Surface plasmon resonance response curves elicited by binding of SEN1269 (0.5, 1, 3, 5, 10, 15, 20 and 30 µM) to monomeric Aβ1–42. (B) Thioflavin-T fluorescence concentration–response curves of compounds incubated with 10 µM Aβ1–42 for 24 h. (C) Concentration–response curves of compounds incubated with 10 µM Aβ1–42 for 24 h on SHSY5Y cells using MTT colorimetric assay (cell viability level for 10 µM Aβ1–42 was 10%).