Figure 5.

Activation of α7 nACh receptors selectively attenuates carrageenan-induced pro-inflammatory cytokine levels in the rat hind paw. The rats were administered either diclofenac (10 mg·kg⁻¹, p.o., t =−120 min), compound B (30 mg·kg⁻¹, s.c., t =−30 min), PNU-120596 (30 mg·kg⁻¹, i.p., t =−30 min) or vehicle (15% MBCD) at the time (t) indicated before injection of either carrageenan or vehicle (sham) in the hind paw and determination of effects on hind paw oedema-associated levels of the pro-inflammatory cytokines (A) TNF-α, (B) IL-1β and (C) IL-6 at 2 h post-carrageenan. ^###P < 0.001 versus Veh + sham; *P < 0.05, **P < 0.01 versus Veh + Carr (one-way anova followed by Student Newman–Keuls t-test).