Table 3.

Effects of compound B and PNU-120596 on motor function and coordination in the rotarod test

Drug	Dose (mg·kg−1)	% Baseline
Vehicle		100 ± 0 (180 ± 0 s)
Compound B	30	89.9 ± 6.7
	60	52.6 ± 5.2*
PNU-120596	60	85.3 ± 9.7
Diazepam	5	30.8 ± 14.1*

Normal, uninjured rats were administered either drug or vehicle (15% MBCD) immediately after a baseline response had been obtained and the maximal effects on activity-induced motor performance (represented as % baseline) determined 30 min later. Numbers in parentheses represent raw untransformed data for vehicle-treated animals. All groups n= 8 rats. Data are presented as mean ± SEM.

^*P < 0.001 versus vehicle (one way anova followed by Bonferroni's t-test).