Table 1. Characterization of mesenchymal subtype-like U87-2M1 glioma cells by DNA microarray analysis.

Gene ontology term	Enrichment score	Count	%	P-value	FDR
(a) Enriched gene clusters in U87-2M1 glioma cellsa
GO:0007155
Cell adhesion	7.16	72	7.64	5.27E−08	9.52E−05
GO:0048731
System development	5.33	182	19.3	8.15E−09	1.47E−05
GO:0001944
Vasculature development	5.12	37	3.92	7.75E−08	1.40E−04
GO:0043062
Extracellular structure organization	3.89	30	3.18	1.11E−08	2.01E−05
GO:0042060
Wound healing	3.46	27	2.86	9.07E−06	1.64E−02
GO:0048513
Organ development	3.32	132	14.0	8.21E−06	1.48E−02
(b) Enriched gene clusters in U87-2M1 glioma cells after miR-10b silencingb
GO:0019222
Regulation of metabolic process	6.93	401	24.4	1.36E−11	2.53E−08
GO:0042127
Regulation of cell proliferation	5.26	111	6.74	2.99E−08	5.53E−05
GO:0048522
Positive regulation of cellular process	5.05	221	13.4	6.95E−09	1.29E−05
GO:0032502
Developmental process	4.52	333	20.2	3.42E−07	6.34E−04
GO:0000280
Nuclear division	3.86	39	2.37	1.19E−05	2.21E−02
GO:0051270
Regulation of cell motion	3.67	35	2.13	2.22E−05	4.10E−02
GO:0001944
Vasculature development	3.61	43	2.61	9.54E−06	1.77E−02
GO:0043067
Regulation of programmed cell death	3.56	105	6.38	4.85E−06	8.99E−03

Abbreviation: FDR, false discovery rate

^aGenes that were differentially regulated by more than twofolds between U87-2M1 and U87 cells were screened using DAVID version 6.7, for enriched biological themes. Six most enriched gene ontology terms are listed

^bGenes that were differentially regulated by more than 1.5-fold after miR-10b silencing in U87-2M1 cells were screened with DAVID version 6.7, for identification of biological themes. Eight most enriched gene ontology terms are listed