. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: Cancer. 2012 Mar 20;118(21):5358–5365. doi: 10.1002/cncr.27528

Table 3.

Overall PFS Estimates by Method

Progression Date Determination Method	NCCTG		SWOG

	NSCLC (n=660)	SCLC (n=116)	NSCLC (n=297)	SCLC (n=131)

Method 1
Median PFS (95% CI)^*	4.3 (3.8-4.7)	2.7 (1.6-4.2)	3.1 (2.5-4.1)	1.3 (1.2-1.6)
6-month estimate (%)	36.5 (32.9-40.4%)	21.5 (15.1-30.6%)	31.0 (26.1-36.7%)	10.7 (6.5-17.5%)
1-year estimate (%)	12.3 (9.9-15.3%)	3.8 (1.4-9.8%)	12.5 (9.2-16.8%)	3.8 (1.6-9.0%)

Method 2
Median PFS (95% CI)^*	3.3 (2.7-3.6)	1.8 (0.8-3.3)	2.2 (1.6-2.8)	0.7 (0.6-0.8)
6-month estimate (%)	28.1 (24.7-31.8%)	13.6 (8.6-21.7%)	23.6 (19.1-29.1%)	6.7 (3.4-13.1%)
1-year estimate (%)	8.9 (6.8-11.7%)	1.0 (0.1-6.9%)	8.6 (5.8-12.6%)	3.4 (1.3-8.8%)

Method 3
Median PFS (95% CI)^*	1.8 (1.6-2.0)	0.03 (0.03-1.4)	1.5 (1.2-1.7)	0.03 (n/a)
6-month estimate (%)	17.1 (14.4-20.3%)	4.7 (2.0-11.0%)	17.2 (13.4-22.0%)	5.3 (2.6-11.0%)
1-year estimate (%)	7.9 (5.9-10.6%)	1.3 (0.2-8.1%)	6.4 (4.1-9.9%)	3.1 (1.2-8.0%)

Method 4
Lower, Upper ^*	3.45, 3.52	1.45, 1.45	2.79, 2.86	0.03, 0.03

Estimates are in months.