Table 4.

PFS Comparisons for Randomized Trials

Trial	Progression Date Determination Method
	Method 1 (median PFS)*	Method 2 (median PFS)*	Method 3 (median PFS)*	Method 4 (lower, upper)*
Trial 1
Arm A	4.6	2.9	3.7	3.94, 4.24
Arm B	3.6	1.6	2.6	2.46, 3.02
Arm C	4.2	1.6	3.4	4.14, 4.20
P value †	0.59	0.24	0.32	0.67
Trial 2
Arm A	5.7	3.1	4.6	4.47, 4.60
Arm B	4.9	1.6	2.9	4.63, 4.99
P value †	0.25	0.19	0.18	0.25
Trial 3
Arm A	3.1	1.3	2.1	2.60, 2.60
Arm B	3.8	1.5	3.4	3.48, 4.11
P value †	0.38	0.40	0.50	0.67
Trial 4
Arm A	6.7	4.0	5.5	4.07, 4.11
Arm B	5.2	3.3	4.2	3.25, 3.84
P value ‡	0.43	0.35	0.39	0.77

^†P value for arm comparison: Log-rank test

^‡P value for arm comparison: Generalized Log-rank test

^*Estimates in months.