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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Exp Dermatol. 2012 Oct;21(10):771–777. doi: 10.1111/exd.12012

Figure 4.

Figure 4

Forskolin-mediated epidermal thickening is photoprotective. (a, b) Transmission of (a) UVA (315–390 nm) or (b) UVB (265–332 nm) through whole depilated dorsal skins of age-matched K14-Scf animals treated (3wk, 5d/wk) as indicated (n=5 animals per group). Untreated K14-Scf Mc1rE/E Tyr+/+ (wild type) animals animals are included as “maximally pigmented” eumelanotic controls. (c) Quantification of sunburn cells 24h after UV exposure in albino extension animals pre-treated (3wk, 5d/wk) with either vehicle (n=4) or forskolin (n=5) and exposed to the indicated dose of UVB. The inset shows an example of a sunburn cell dense and (d) describes mean epidermal thickness of cohorts of animals used in the sunburn cell assay. * p ≤ 0.05.