Table 1.
Amino Acid Sequences and Key NOEs of ABSMs 1a–q. | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Sequence | R1–R7 | R8–R11 | Ornα-δS | 2–10 | 4-Hao6 | 6–9 | Ornα–δS | Folding | ||
1a | Aβ16–22 | KLVFFAE | KLIE | Sa | —b | S | S | S | good | |
1b | Aβ17–23 | LVFFAED | KLIE | S | S | S | S | S | good | |
1c | Aβ29–35 | GAIIGLM | KFYK | S | S | S | S | S | good | |
1d | Aβ30–36 | AIIGLMV | KFYK | S | S | S | S | S | good | |
1e | Aβ30–36 G33F | AIIFLMV | KFYK | S | S | S | S | S | good | |
1f | Aβ34–40 | LMVGGVV | KFYK | S | S | Wa | —c | S | moderate | |
1g | Aβ34–40 G37F | LMVFGVV | KFYK | S | S | S | S | S | good | |
1h | Sup357–13 | GQQNNQY | KFYK | W | —c | —c | —c | W | poor | |
1i | hPrP116–122 | AAAGAVV | KFYK | W | W | —c | —c | W | poor | |
1j | Tau305–311 | SVQIVYK | EFYK | S | S | S | S | S | good | |
1k | hβ2M62–68 | FYLLYYT | KNSA | S | S | S | —b | S | good | |
1l | hβ2M63–69 | YLLYYTE | FKVS | W | —c | —c | —c | W | poor | |
1m | hβ2M63–69 | YLLYYTE | KVVK | S | —d | S | —d | S | good | |
1n | hαSyn69–75 | AVVTGVT | KFYV | S | S | S | —d | S | good | |
1o | hαSyn75–81 | TAVANKT | VFYK | S | S | S | —d | S | good | |
1p | hIAPP11–17 | RLANFLV | KFYK | S | S | S | S | S | good | |
1q | hIAPP26–32 | ILSSTNV | KFYK | S | S | S | S | S | good | |
1r | Aβ30–36 | AIIGLMV | KFFBr | K |
S: strong NOE; W: weak NOE.
NOE not observed due to overlap of proton resonances.
NOE not observed.
NOE not able to be observed due to overlap with HOD.