FIGURE 4.

Changes in the residue enviromental parameters. A, mobility ΔH_o⁻¹. B, O₂ accessibility ΠO₂ for the closed (black) and desensitized (red) states. Shown is the profile of changes in the enviromental parameters for the M2 residues (left). Shown is a helical wheel representation of the mobility and accessibility superimposed in a polar coordinate (middle). The resultant vector of the individual ΔH_o⁻¹ or ΠO₂ values points toward the more mobile or solvent accessible face of the helix. The shaded area within the dashed lines highlights the projection for complete set of accessibility data relative to the maximal accessibility vector. Fractional differences (normalized to the maximum value measured within each data set) in the ΔH_o⁻¹ and ΠO₂ values for the closed and desensitized states mapped on the GLIC structure and color coded, with red denoting an increase and blue representing a decrease in the environmental parameter (right).