FIGURE 4.

Inhibition of VahC, Photox, and SpvB mART activity. A, structures of inhibitor compounds effective in reducing mART activity of VahC, Photox, and SpvB. B, IC₅₀ determinations of VahC by suramin (white circles), V31 (black circles), V7 (white squares), and V8 (black squares). Activity loss was assessed as described under “Experimental Procedures.” C, relative inhibition of Photox (gray), VahC (black), and SpvB (white). Activities were compared in the presence and absence of each inhibitor at its respective IC₅₀ concentration against VahC using reaction conditions described under “Experimental Procedures.” Error bars, S.D.