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PDK1 is decreased in cortical extracts from AD patients. Top panels, immunoblot analysis of post-mortem human cortical extracts revealed decreased PDK1 levels in human AD brain samples (A1–A7) when compared with the age- and sex-matched controls (1–7). Bottom panel, densitometric analysis of the above blot revealed a significant decrease in PDK1 expression in AD patients compared with controls (*, p < 0.01).
