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. 2012 Sep 7;287(44):37434–37446. doi: 10.1074/jbc.M112.406090

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — R206E shows specificity for BCMA, whereas D132Y and D132F show selectivity for TACI. Binding activity of the ligands was tested on TACI:Fas- and BCMA:Fas-expressing reporter cells. The ligand binding is directly associated with induced cell death. A, staining for human BCMA and TACI on Jurkat BCMA:Fas (left) and Jurkat JOM2 TACI:Fas cells (right). B and C, measurement of cell death produced after a 16-h treatment with doubling dilutions of the APRIL variants on BCMA:Fas (B) and TACI:Fas (C) reporter cells. D, microscopic pictures (×40) of Jurkat-BCMA-Fas (top) and Jurkat-TACI-Fas (bottom) cells after a 1-h stimulation with the indicated APRIL variants. Conditioned media were matched for APRIL amounts before incubation.