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. 2012 Aug 6;287(44):37483–37494. doi: 10.1074/jbc.M112.386821

FIGURE 4.

FIGURE 4.

Bbs12−/− mouse presents retinal degeneration. A, toluidin blue-stained sections of the WT (Bbs12+/+, left panel) and KO (Bbs12−/−, right panel) retinas at 4 weeks of age. Scale bars, 50 μm. B, determination of ONL thickness of the WT and KO mice at 4 weeks (n = 6). *, p < 0.01. C, transmission electron microscopy (TEM) pictures of the outer segments of WT and KO retinas at 4 weeks. Scale bars, 1 μm. Arrows point to disk dilatation. D, scotopic ERG recordings for specified genotypes at 4 weeks. Red arrows present a-waves. E and F, immunostaining of Rhodopsin (E, Rho) and Arrestin (Arr, F) in WT and KO retinas at 4 weeks with DAPI and OS counterstaining using Agglutinin (Agg). Scale bars, 20 μm. G, transmission electron microscopy analysis of inner segments with ER cisternae encircled in red at 4 weeks of age. Scale bars, 200 nm. INL, inner nuclear layer.