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. 2012 Aug 6;287(44):37483–37494. doi: 10.1074/jbc.M112.386821

FIGURE 6.

FIGURE 6.

Pharmacological modulation of UPR prevents photoreceptors loss in Bbs12−/− retina. A, immunostaining of acetylated α-tubulin with DAPI counterstaining in indicated treated animals at 4 weeks of age. Scale bars, 20 μm. B, comparison of ONL length of GIVin treated and untreated mice at 4 weeks of age (n = 6). *, p < 0.01. C, immunodetection of BiP, peIF2α, eIF2αtot, CHOP10, and Rhodopsin in retinas from indicated treated 4-week-old animals. See supplemental Fig. S11 for loading controls and quantification. D, scotopic ERG recordings of animals with indicated treatment and genotype at 4 weeks of age. E, scotopic a-wave amplitude versus stimulus intensity (log) function of animals with indicated treatment and genotype at 4 weeks of age (n = 12). *, p < 0.05. F, scotopic b-wave amplitude versus stimulus intensity (log) function of indicated animals (n = 12). **, p < 0.05. The animals were treated for 2 weeks with GIVin: topical GBZ 7,5 μm + topical INH 500 μm + systemic VPA 5 mg/ml.