TABLE 1.

Predicted distribution of representative transcription factors on the CSIG, PCNA, CCNA2, ARF, and p27^KIP1 promoter from TFSCAN

Representative TFs	Down-regulated E2F target genes in senescent cells			Up-regulated E2F target genes in senescent cells
	CSIG	PCNA	CCNA2	ARF	p27KIP1
Sp1	+	+	+	+	+
c-Ets-2	+	+	+	+	+
E2F	+	+	+	+	+
GATA-1	+	−	−	+	+
MAZ	+	−	−	+	+
CREB	+	−	−	+	−
TBP	+	−	−	−	+
LF-A1	+	−	+	+	+
H4TF-2	+	+	+	+	+
c-Myb	+	+	+	−	−