Table 2.
Twenty most significantly enriched (FDR < 0.05) GeneGo pathways among differentially expressed genes after miR-7 (A) or miR-128 (B) transfection into HEY cells
|
A. | |
|---|---|
| Pathways enriched among miR-7 modulated genes | p-value |
| Cell adhesion_Chemokines and adhesion |
1.31E-07 |
| Cell cycle_Regulation of G1/S transition (part 1) |
8.68E-07 |
| Cell adhesion_Ephrin signaling |
3.96E-06 |
| Development_EGFR signaling pathway |
1.02E-05 |
| Development_ERBB-family signaling |
1.13E-05 |
| Development_WNT signaling pathway. Part 1. Degradation of beta-catenin in the absence WNT signaling |
1.42E-05 |
| Development_VEGF-family signaling |
1.68E-05 |
|
Cytoskeleton remodeling_Cytoskeleton remodeling |
3.13E-05 |
|
Neurophysiological process_Receptor-mediated axon growth repulsion |
3.43E-05 |
| Proteolysis_Putative ubiquitin pathway |
3.44E-05 |
| Development_TGF-beta-dependent induction of EMT via RhoA, PI3K and ILK. |
4.05E-05 |
| Cell adhesion_Plasmin signaling |
4.85E-05 |
| Development_TGF-beta-dependent induction of EMT via SMADs |
4.85E-05 |
| Transport_RAB5A regulation pathway |
5.75E-05 |
|
Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling |
7.29E-05 |
| Cell cycle_Regulation of G1/S transition (part 2) |
7.30E-05 |
| Apoptosis and survival_HTR1A signaling |
7.54E-05 |
| Development_Regulation of epithelial-to-mesenchymal transition (EMT) |
7.67E-05 |
| Translation _Regulation of EIF2 activity |
1.01E-04 |
| Cell adhesion_ECM remodeling |
1.01E-04 |
|
B. | |
|
Pathways enriched among miR-128 modulated genes |
p-value |
| Cell cycle_The metaphase checkpoint |
1.01E-11 |
|
Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling |
1.29E-09 |
| Cell cycle_Role of Nek in cell cycle regulation |
1.77E-09 |
| Transport_Clathrin-coated vesicle cycle |
4.15E-09 |
| Cell cycle_Initiation of mitosis |
4.37E-09 |
| Immune response_Histamine H1 receptor signaling in immune response |
1.78E-07 |
| Cell cycle_Role of APC in cell cycle regulation |
1.79E-07 |
| Cell cycle_Spindle assembly and chromosome separation |
2.75E-07 |
|
Cytoskeleton remodeling_Cytoskeleton remodeling |
2.98E-07 |
| Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway |
3.68E-07 |
| Cytoskeleton remodeling_Neurofilaments |
6.14E-07 |
| Cell cycle_Chromosome condensation in prometaphase |
8.18E-07 |
| Immune response_Gastrin in inflammatory response |
1.85E-06 |
|
Neurophysiological process_Receptor-mediated axon growth repulsion |
2.69E-06 |
| Translation_Non-genomic (rapid) action of Androgen Receptor |
3.55E-06 |
| Development_PIP3 signaling in cardiac myocytes |
4.80E-06 |
| Cytoskeleton remodeling_Role of Activin A in cytoskeleton remodeling |
5.34E-06 |
| Apoptosis and survival_Apoptotic Activin A signaling |
5.76E-06 |
| Apoptosis and survival_BAD phosphorylation |
6.54E-06 |
| Immune response_Fc epsilon RI pathway | 7.40E-06 |
The pathways that are enriched among differentially expressed genes after both miR-7 and miR-128 transfection are highlighted in bold.