Fig. 1.

An exceptional case, mouse #3, was assigned to the poor response group although it showed a large area of necrosis (NF=0.49). (A) Serial DCE-MRI with color mapping shows the change in K^trans. Pretreatment K^trans showed a relatively low value (0.11). K^trans increased after the first radiation therapy (K₁R=1.51). Red color represents the higher value of K^trans and blue color represents the lower value. An outgrowing tumor was identified after the first radiation therapy (arrow). (B) H&E staining of the newly grown tumor, which separated from the main mass, showed rare necrosis. The original magnification is ×2. The red line indicates the tumor border and the blue line indicates the area of necrosis. NF, necrotic fraction; H&E, hematoxylin and eosin.