Figure 4.

Web Interface for C²Maps basic query function. (a) C²Maps default home page with a query box; (b) Preference configuration page with editable parameters in network mining component and text mining component; (c) Disease-specific protein-drug connectivity map page shows disease-relevant proteins, their ranking score, and drugs, their p-value, their relative frequency, as well as evidences supporting the protein-drug associations; (d) Filter result page shows the subset of the connectivity map; (e) Protein detail page shows the disease-related protein, its partner proteins in interaction network, and related drugs in retrieved abstracts; (f) Drug detail page shows the disease-related drugs, its neighbor drugs in Medical Subject Heading Tree, and related proteins in disease-specific protein interaction network; (g) Article detail page shows the literature references in PubMed with protein entity and drug entity highlighted.